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Review
. 2014 Apr-May;13(4-5):569-73.
doi: 10.1016/j.autrev.2014.01.014. Epub 2014 Jan 12.

Idiopathic aplastic anemia: diagnosis and classification

Osnat Jarchowsky Dolberg  1 , Yair Levy  2
Affiliations
Review

Idiopathic aplastic anemia: diagnosis and classification

Osnat Jarchowsky Dolberg et al. Autoimmun Rev. 2014 Apr-May.

Abstract

Aplastic anemia (AA) is a disease characterized by pancytopenia and hypoplastic bone marrow caused by the decrease of hematopoietic stem cells. The pathogenesis of AA is complex and involves an abnormal hematopoietic microenvironment, hematopoietic stem cell/progenitor cell deficiencies and immunity disorders. Survival in severe aplastic anemia (SAA) has markedly improved in the past 4 decades because of advances in hematopoietic stem cell transplantation, immunosuppressive and biologic drugs, and supportive care. Herein, we will update the main issues concern AA according to our literature review.

Keywords: Aplastic anemia; Autoimmunity; Immunosuppressive therapy; Pancytopenia.

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