The use of platelet-rich plasma gel in patients with mixed tumour undergoing superficial parotidectomy: a randomized study

Abstract

Background/aim: Salivary gland tumors are mostly benign tumors. Whether a more conservative surgical approach at greater risk of recurrence, or a more radical intervention with an increased risk of facial paralysis is warranted is still under discussion. Our study addresses the opportunity for improving surgical outcome by employing platelet-rich plasma (PRP) gel at the surgical site.

Patients and methods: Twenty consecutive patients undergoing superficial parotidectomy were randomized and assigned to two groups, one with and one without PRP gel. Many parameters were evaluated after surgery and during follow-up, such as the duration of hospitalization, facial nerve deficit, onset of Frey's syndrome, relapse, cosmetic results, presence of keloid or scar depressions, behavior of several facial muscles.

Results: Our explorative analysis suggests a positive effect of PRP on surgical outcome in patients undergoing parotidectomy, whereas no negative effects were detected.

Conclusion: This work suggests that administration of PRP in patients undergoing parotidectomy is beneficial.

Keywords: Regenerative medicine; parotidectomy; platelet gel; platelet-rich plasma; salivary gland tumors.