Anti-pathogenic Potential of Coral Associated Bacteria Isolated from Gulf of Mannar Against Pseudomonas aeruginosa

doi:10.1007/s12088-012-0342-3

. 2013 Mar;53(1):111-3.

doi: 10.1007/s12088-012-0342-3. Epub 2012 Dec 18.

Anti-pathogenic Potential of Coral Associated Bacteria Isolated from Gulf of Mannar Against Pseudomonas aeruginosa

Dhamodharan Bakkiyaraj¹, Chandran Sivasankar¹, Shunmugiah Karutha Pandian¹

Affiliations

PMID: 24426087
PMCID: PMC3587518
DOI: 10.1007/s12088-012-0342-3

Anti-pathogenic Potential of Coral Associated Bacteria Isolated from Gulf of Mannar Against Pseudomonas aeruginosa

Dhamodharan Bakkiyaraj et al. Indian J Microbiol. 2013 Mar.

. 2013 Mar;53(1):111-3.

doi: 10.1007/s12088-012-0342-3. Epub 2012 Dec 18.

Authors

Dhamodharan Bakkiyaraj¹, Chandran Sivasankar¹, Shunmugiah Karutha Pandian¹

Affiliation

¹ Department of Biotechnology, Alagappa University, Karaikudi, 630003 TN India.

PMID: 24426087
PMCID: PMC3587518
DOI: 10.1007/s12088-012-0342-3

Abstract

Infections of Pseudomonas aeruginosa are of great concern because of its increasing resistance towards conventional antibiotics. Quorum sensing system of P. aeruginosa acts as a global regulator of almost all the virulence factors and majorly its biofilm formation. In the present study, quenching of QS system of P. aeruginosa has been explained with bioactives from bacteria associated with the coral Acropora digitifera. Isolated bioactives inhibited the expression of various virulence traits of P. aeruginosa like biofilm formation, and the production of extracellular enzymes like protease and elastase. This study also emphasises the potential of coral associated bacteria in producing bioactive agents with anti-pathogenic properties.

Keywords: Anti-QS; Biofilm; Coral associated bacteria; Pseudomonas aeruginosa; Quorum sensing; Quorum sensing inhibitor.

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Figures

**Fig. 1**
a Screening of CAB isolates for anti-QS activity by agar overlay method using *C. violaceum* ATCC 12472 as an indicator organism. b Confocal microscopy images showing the reduction in surface area covered by biofilms treated with CAB23 and 41 extracts

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References

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[1] Karatuna O, Yagci A. Analysis of quorum sensing-dependent virulence factor production and its relationship with antimicrobial susceptibility in Pseudomonas aeruginosa respiratory isolates. Clin Microbiol Infect. 2010;16:1770–1775. doi: 10.1111/j.1469-0691.2010.03177.x. - DOI - PubMed

[2] Karatuna O, Yagci A. Analysis of quorum sensing-dependent virulence factor production and its relationship with antimicrobial susceptibility in Pseudomonas aeruginosa respiratory isolates. Clin Microbiol Infect. 2010;16:1770–1775. doi: 10.1111/j.1469-0691.2010.03177.x. - DOI - PubMed

[3] Rasmussen TB, Givskov M. Quorum-sensing inhibitors as anti-pathogenic drugs. Int J Med Microbiol. 2006;296:149–161. doi: 10.1016/j.ijmm.2006.02.005. - DOI - PubMed

[4] Rasmussen TB, Givskov M. Quorum-sensing inhibitors as anti-pathogenic drugs. Int J Med Microbiol. 2006;296:149–161. doi: 10.1016/j.ijmm.2006.02.005. - DOI - PubMed

[5] Adonizio A, Kong KF, Mathee K. Inhibition of quorum sensing-controlled virulence factor production in Pseudomonas aeruginosa by South Florida plant extracts. Antimicrob Agents Chemother. 2008;52:198–203. doi: 10.1128/AAC.00612-07. - DOI - PMC - PubMed

[6] Adonizio A, Kong KF, Mathee K. Inhibition of quorum sensing-controlled virulence factor production in Pseudomonas aeruginosa by South Florida plant extracts. Antimicrob Agents Chemother. 2008;52:198–203. doi: 10.1128/AAC.00612-07. - DOI - PMC - PubMed

[7] Choo JH, Rukayadi Y, Hwang JK. Inhibition of bacterial quorum sensing by vanilla extract. Lett Appl Microbiol. 2006;42:637–641. - PubMed

[8] Choo JH, Rukayadi Y, Hwang JK. Inhibition of bacterial quorum sensing by vanilla extract. Lett Appl Microbiol. 2006;42:637–641. - PubMed

[9] Ni N, Li M, Wang J, Wang B. Inhibitors and antagonists of bacterial quorum sensing. Med Res Rev. 2009;29:65–124. doi: 10.1002/med.20145. - DOI - PubMed

[10] Ni N, Li M, Wang J, Wang B. Inhibitors and antagonists of bacterial quorum sensing. Med Res Rev. 2009;29:65–124. doi: 10.1002/med.20145. - DOI - PubMed

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Anti-pathogenic Potential of Coral Associated Bacteria Isolated from Gulf of Mannar Against Pseudomonas aeruginosa

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Anti-pathogenic Potential of Coral Associated Bacteria Isolated from Gulf of Mannar Against Pseudomonas aeruginosa

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