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Case Reports
. 2013 Sep;29(3):155-7.
doi: 10.1007/s12288-012-0159-6. Epub 2012 May 3.

Hemolytic Disease of the Newborn Due to Anti-c Isoimmunization: A Case Report

C S Sheeladevi  1 , S Suchitha  2 , G V Manjunath  2 , Srinivas Murthy  2
Affiliations
Case Reports

Hemolytic Disease of the Newborn Due to Anti-c Isoimmunization: A Case Report

C S Sheeladevi et al. Indian J Hematol Blood Transfus. 2013 Sep.

Abstract

The Rhesus (Rh) blood group is one of the most complex blood groups known in humans. It has remained of primary importance in obstetrics, being the main cause of hemolytic disease of the newborn (HDN). Anti-D causes the most severe form of HDN. Other Rh allo antibodies that are capable of causing severe HDN include anti-c, which clinically is the most important Rh antigen after the D antigen. We report a case of hemolytic disease of the newborn due to Rh anti-c in an infant of an Rh positive mother.

Keywords: Anti-c; Hemolytic disease; New born.

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Figures

Fig. 1
Fig. 1
Normoblasts, spherocytes, polychromatophilic erythrocytes in peripheral smear (Leishman’s, ×400)
Fig. 2
Fig. 2
Reticulocytosis (Brilliant cresyl blue, ×1000)
Fig. 3
Fig. 3
Positive direct Coomb’s test (Gel matrix method)
See this image and copyright information in PMC

References

    1. Chavez GF, Mulinare J, Edmonds LD. Epidemiology of Rh hemolytic disease of the newborn in the United States. JAMA. 1991;265(24):4–3270. doi: 10.1001/jama.1991.03460240066029. - DOI - PubMed
    1. Dean L (2006) The Rh blood group. In: Blood groups and red cell antigens. National library of medicine (US), NCBI, Bethesda
    1. Sana A, Safae H, Chekabab H, Abdelhak B, Moustapha H (2009) Hemolytic disease of the newborn due to anti-c. BMJ Case Rep. doi:10.1136/bcr:09.2008.0987 - PMC - PubMed
    1. Geoff D, Imelda B (2007) The Rh blood group system. In: Essential guide to blood groups. Blackwell Publishing, Amsterdam, pp 33–44
    1. Singla S, Kumar S, Kumar RK, Sharma JB, Kachhawa G. Severe hydrops in the infant of a Rhesus D positive mother due to anti-c antibodies diagnosed antenatally: a case report. J Case Rep. 2010;4:57. doi: 10.1186/1752-1947-4-57. - DOI - PMC - PubMed

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