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. 2013 Apr;75(2):102-5.
doi: 10.1007/s12262-012-0428-5. Epub 2012 Mar 27.

Correlation of biochemical markers of primary hyperparathyroidism with single adenoma weight and volume

F Kamani  1 , A Najafi  2 , S S Mohammadi  1 , S Tavassoli  2 , S P Shojaei  2
Affiliations

Correlation of biochemical markers of primary hyperparathyroidism with single adenoma weight and volume

F Kamani et al. Indian J Surg. 2013 Apr.

Abstract

Preoperative laboratory markers of primary hyperparathyroidism including serum parathormone (PTH), calcium and phosphate level may have some predictive value about the size and volume of the abnormal parathyroid gland tissue which needs to be resected in primary hyperparathyroidism. In a Prospective study from 2003 to 2010, 69 patients with parathyroid adenoma were enrolled. The correlation between preoperative serum PTH, calcium and phosphate level with adenoma's weight and volume was analyzed separately. Adenoma volume was calculated via an equation for the volume of a spheroid object. The data were analyzed via a multiple analysis of variance, and a correlation coefficient was calculated. The level of significance was set at p _ .05. There was a significant correlation between adenoma weight and serum calcium and parathormone levels (p = .0001 and p = .0001, respectively). There was no significant correlation between adenoma weight and serum phosphate. With respect to adenoma weight, there was a significant relationship with parathormone levels and serum calcium (p = .0001 and p = .0001, respectively). There was no significant relationship between serum phosphate and aden2oma weight. Preoperative serum PTH and calcium levels may be valuable in predicting parathyroid adenoma volume and weight in primary hyperparathyroidism for a single adenoma.

Keywords: Adenoma; Biochemical markers; Primary hyperparathyroidism; Volume; Weight.

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Figures

Fig. 1
Fig. 1
Correlation between adenoma’s weight and serum PTH level (r = 0.381, p = ,001)
Fig. 2
Fig. 2
Correlation between adenoma’s weight and serum calcium (Ca) level (r = 0.317. p = 0.008)
Fig. 3
Fig. 3
Correlation between adenoma’s volume and serum PTH level (r = 0.327, p = 0.006)
Fig. 4
Fig. 4
Correlation between adenoma’s volume and serum calcium (Ca) level (r = 0.333, p = 0.005)
See this image and copyright information in PMC

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