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. 2013 Aug;23(4):430-8.

Combination of probiotics and antibiotics in the prevention of recurrent urinary tract infection in children

Mohammad-Javad Mohseni  1 , Zahra Aryan  1 , Sahra Emamzadeh-Fard  1 , Koosha Paydary  1 , Vahid Mofid  2 , Hasan Joudaki  2 , Abdol-Mohammad Kajbafzadeh  1
Affiliations

Combination of probiotics and antibiotics in the prevention of recurrent urinary tract infection in children

Mohammad-Javad Mohseni et al. Iran J Pediatr. 2013 Aug.

Abstract

Objective: We examined the preventive effect of probiotic and antibiotics versus antibiotics alone, in children with recurrent urinary tract infections (RUTI) in a preliminary randomized clinical trial.

Methods: Between March 2007 and April 2011, children with the history of RUTI and unilateral vesicoureteral reflux (VUR) were randomly assigned to receive concomitant probiotic and antibiotics (Lactobacillus acidophilus and bifidobacterium lactis, 10(7)/ml, as 0.25 ml/kg three times a day regimen in addition to Nitrofurantoin, 1mg/kg daily (group I). In group II, all children received conventional prophylactic antibiotics alone (Nitrofurantoin, 1 mg/kg daily). Randomization was performed via using the random numerals table in a 1:1 manner with stratification by sex, age and grade of reflux. The urine examinations were done monthly and the incidence of UTI was evaluated in these two groups.

Findings: Forty-one children (age: 8.3±3.1 years) in group I and 44 children (age: 8.0±3.0 years) in group II were compared. During the course of three years, 39% in group I and 50% of participants in group II experienced RUTIs (P=0.4). Incidences of UTI - febrile and afebrile - reduced in both groups without any significant differences after two years of prophylaxis. Also, incidence of afebrile UTIs did not significantly differ (0.51±1.30 and 0.81±1.41 respectively, P =0.3); however, the incidence of febrile UTIs in particular were lower in group I (0.00±0.00 versus 0.13±0.40, P =0.03) in the last year.

Conclusion: The consumption of probiotic and antibiotics in children with RUTI is safe and more effective in reducing the incidence of febrile UTI in comparison to prophylactic antibiotics alone.

Keywords: Antibiotic Prophylaxis; Bifidobacterium Lactis; Lactobacillus Acidophilus; Urinary Tract Infection; Vesicoureteral Reflux.

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Figures

Fig. 1
Fig. 1
Flow diagram of the study
Fig. 2
Fig. 2
Recurrent Urinary tract infections and responsible pathogens in two groups of study (P=0.3)
See this image and copyright information in PMC

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