Clinico-pathological study of 50 cases of tumours of larynx

Abstract

The larynx serves to protect the lower airways, facilitates respiration and plays a key role in phonation. Based on anatomic location, the larynx is divided into the supraglottic larynx, the glottis or glottic larynx, and the subglottic larynx. The tumours of larynx can be divided into benign or malignant. Laryngeal granulomas, Vocal cord nodules, Vocal cord polyps are tumour-like lesions of larynx. Benign laryngeal tumors include a large number of lesions like papillomas, hemangiomas, fibromas, chondromas, myxomas, and neurofibromas. About 95% of laryngeal carcinomas are typical squamous cell tumours. Rarely adenocarcinomas are seen, presumably arising from mucous glands. The exact cause of laryngeal cancer is still unknown. Diagnosis is based on direct or indirect visualization of the larynx, supplemented by CT scan and confirmed by histopathological examination.

Objective: The aim of the present study was to study the clinical aspects, histopathological patterns of tumours of the larynx to study the various predisposing factors of laryngeal tumours. The present study was undertaken on 50 patients clinically diagnosed as cases of tumour of larynx. These patients were made to undergo direct laryngoscopy and the biopsy taken from the growth in the larynx was sent to the department of pathology for histopathological examination. Smoking played the main role in benign growths (25%). The main predisposing factor (73.2%) for malignant growths was smoking, tobacco chewing and alcohol abuse. The most common benign tumour of larynx was the vocal polyp. Out of the 30 cases of squamous cell carcinoma, 15 (50%) were well differentiated, 8 (26.6%) were moderately differentiated and 3 (10%) were poorly differentiated. The symptoms of laryngeal tumours can vary from mild hoarseness of voice to life threatening respiratory distress. All available methods of study should be utilized to make the diagnosis as early as possible. Early diagnosis of the lesion can lead to effective management.

Keywords: Clinicopathological; Histopatholigcal; Laryngeal tumours; Larynx.

Fig. 1

50 Tumours of larynx: predisposing factors

Fig. 2

Well differentiated SCC (H&E 40×)