KTP Laser in Laryngeal Amyloidosis: Five Cases with Review of Literature

Abstract

To study the clinical presentation and review the options in the management of laryngeal amyloidosis. To study the efficacy of KTP 532 laser in the excision of laryngeal amyloidosis. Study was conducted in our department in a tertiary care hospital between Jan 2001 and Feb 2010. We report five patients who presented with hoarseness of voice and localized laryngeal lesions. The biopsy proven laryngeal amyloidosis lesions were excised microendoscopically using KTP 532 laser in three patients and other two patients were kept only on follow-up as they refused further surgery. The patients were evaluated for systemic amyloidosis. The average duration of follow up was 2.6 years (3 months 6 years). All the five patients in our study were asymptomatic with no evidence of recurrence at their last follow up. In our small case series, KTP 532 laser excision of the laryngeal amyloidosis had a favorable outcome. Long term follow up is required to rule out recurrence and systemic involvement.

Keywords: Amyloidosis; KTP 532 laser; Larynx.

Fig. 1

Photomicrograph illustrating amorphous homogenous material surrounded by lymphocytes, plasma cells (thick arrow) and congested capillaries showing deposition of amorphous material in thin wall (thin arrow) [Haematoxylin and Eosin stain; ×40]

Fig. 2

Microlaryngoscopy showing a firm lesion involving the right ventricular band, right ventricle and anterior commisure (a), follow up showing no recurrence of the laryngeal lesion (b)

Fig. 3

CT scan of the larynx showing thickening in the region of the right ventricular band