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. 2013 Dec;65(Suppl 3):461-7.
doi: 10.1007/s12070-011-0281-z. Epub 2011 Jun 29.

Effectiveness of intratympanic dexamethasone in otitis media with effusion resistant to conventional therapy

Mustafa Paksoy  1 , Gokhan Altin  2 , Mehmet Eken  2 , Umit Hardal  2
Affiliations

Effectiveness of intratympanic dexamethasone in otitis media with effusion resistant to conventional therapy

Mustafa Paksoy et al. Indian J Otolaryngol Head Neck Surg. 2013 Dec.

Abstract

The aim of this study was to determine the efficiency of intratympanic dexamethasone (ITD) injections as a new treatment modality in otitis media with effusion resistant to conventional therapy. We planned a nonrandomized prospective study to determine the safety and effectiveness of the direct administration of dexamethasone into middle ear cavity with chronic eustachian tube dysfunction. This study was applied on 75 ears of 64 patients aged from 12 to 60 years. ITD received 47 ears of 41 patients who had previously been treated by medical or surgical therapy middle ear effusion without resolution classified as study group. They were taken conventional medical therapy again 28 ears of 23 patients classified as a control group. ITDs were administered 0.5 ml/4 mg per mm directly in antero-superior quadrant of tympanic membrane. These injections were repeated once a week for 4 weeks. Results were evaluated by using audiometric and tympanometric measurements 1 and 3 months after the treatments. Audiometric measurement shows that 9.91 dB improvement in the mean air-bone gap 15.17 dB in air conduction (AC) pure-tone averages (PTA) and 5.25 dB bone conduction (BC) PTA. But the control group data showed only 2 dB improvement in the mean air-bone gap, 3 dB AC-PTA and 1.36 dB BC-PTA. Tympanometric improvement was found. In 28 ears of patients (59.6%) like type B or C converted to type A in study group without complication but only in three ears (10.7%) of control group. ITD administration to the middle ear is safe and effective for the treatment of otitis media with effusion or chronic eustachian tube dysfunction. No complications like tympanic membrane perforation and/or sensorineural hearing loss have occurred.

Keywords: Hearing loses; Intratympanic dexamethasone; Otitis media with effusion; Resistant to conventional therapy.

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Figures

Fig. 1
Fig. 1
Mean pure tone audiometric changes of study and control groups before and after treatments. AC and BC pre and posttreatment changes were significant in statically in two groups (P < 0.05). The study group is shown more improvement in hearing levels than control group in AC. Pre before treatment, Post after treatment
Fig. 2
Fig. 2
It is shown the improvement of mean hearing levels in study and control groups of patients with OME in histogram
Fig. 3
Fig. 3
Improvement rates of the middle ears compliance of the patients. The tympanogram changes of patients after treatments in study and control groups. PreT before treatment, PostT after treatment
See this image and copyright information in PMC

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