Mucosal correlates of protection in HIV-1-exposed sero-negative persons

doi:10.1111/aji.12202

Review

. 2014 Aug;72(2):219-27.

doi: 10.1111/aji.12202. Epub 2014 Jan 16.

Mucosal correlates of protection in HIV-1-exposed sero-negative persons

Ruizhong Shen¹, Phillip D Smith

Affiliations

PMID: 24428610
PMCID: PMC4101071
DOI: 10.1111/aji.12202

Review

Mucosal correlates of protection in HIV-1-exposed sero-negative persons

Ruizhong Shen et al. Am J Reprod Immunol. 2014 Aug.

. 2014 Aug;72(2):219-27.

doi: 10.1111/aji.12202. Epub 2014 Jan 16.

Authors

Ruizhong Shen¹, Phillip D Smith

Affiliation

¹ Department of Medicine (Gastroenterology), University of Alabama at Birmingham, Birmingham, AL, USA.

PMID: 24428610
PMCID: PMC4101071
DOI: 10.1111/aji.12202

Abstract

Resistance to HIV-1 infection in HIV-1-exposed sero-negative (HESN) persons offers a promising opportunity to identify mechanisms of 'natural' protection. Unique features of the mucosa in particular may contribute to this protection. Here, we highlight several key issues pertaining to the mucosal correlates of protection in HESN persons, including humoral immune responses, mechanisms of mucosal HIV-1 neutralization, immune cell activation, and role of the microbiota in mucosal responses. We also discuss mucosal model systems that can be used to investigate the mechanisms of resistance in HESN subjects. A clear understanding of the mucosal correlates of protection against HIV-1 in HESN persons will provide critical new insights for the development of effective vaccine and microbicide strategies for the prevention of HIV-1 transmission.

Keywords: HESN; cervicovaginal lavage; genital; immune activation; microbiota; mucosal secretion.

PubMed Disclaimer

Cited by

Role of Different Subpopulations of CD8⁺ T Cells during HIV Exposure and Infection.
Gonzalez SM, Taborda NA, Rugeles MT. Gonzalez SM, et al. Front Immunol. 2017 Aug 7;8:936. doi: 10.3389/fimmu.2017.00936. eCollection 2017. Front Immunol. 2017. PMID: 28824656 Free PMC article. Review.
Antibody-Dependent Cellular Phagocytosis of HIV-1-Infected Cells Is Efficiently Triggered by IgA Targeting HIV-1 Envelope Subunit gp41.
Duchemin M, Tudor D, Cottignies-Calamarte A, Bomsel M. Duchemin M, et al. Front Immunol. 2020 Jun 9;11:1141. doi: 10.3389/fimmu.2020.01141. eCollection 2020. Front Immunol. 2020. PMID: 32582208 Free PMC article.
Challenges in mucosal HIV vaccine development: lessons from non-human primate models.
Tuero I, Robert-Guroff M. Tuero I, et al. Viruses. 2014 Aug 15;6(8):3129-58. doi: 10.3390/v6083129. Viruses. 2014. PMID: 25196380 Free PMC article. Review.
Inflammation, HIV, and Immune Quiescence: Leveraging on Immunomodulatory Products to Reduce HIV Susceptibility.
Cromarty R, Archary D. Cromarty R, et al. AIDS Res Treat. 2020 Oct 27;2020:8672850. doi: 10.1155/2020/8672850. eCollection 2020. AIDS Res Treat. 2020. PMID: 33178456 Free PMC article. Review.
Reducing IRF-1 to Levels Observed in HESN Subjects Limits HIV Replication, But Not the Extent of Host Immune Activation.
Su RC, Plesniarski A, Ao Z, Kimani J, Sivro A, Jaoko W, Plummer FA, Yao X, Ball TB. Su RC, et al. Mol Ther Nucleic Acids. 2015 Oct 27;4(10):e259. doi: 10.1038/mtna.2015.29. Mol Ther Nucleic Acids. 2015. PMID: 26506037 Free PMC article.

See all "Cited by" articles

References

1. Ranki A, Mattinen S, Yarchoan R, Broder S, Ghrayeb J, Lahdevirta J, Krohn K. T-cell response towards HIV in infected individuals with and without zidovudine therapy, and in HIV-exposed sexual partners. AIDS (London, England) 1989;3:63–69. - PubMed
1. Imagawa DT, Lee MH, Wolinsky SM, Sano K, Morales F, Kwok S, Sninsky JJ, Nishanian PG, Giorgi J, Fahey JL, et al. Human immunodeficiency virus type 1 infection in homosexual men who remain seronegative for prolonged periods. N Engl J Med. 1989;320:1458–1462. - PubMed
1. Young JM, Turpin JA, Musib R, Sharma OK. Outcomes of a National Institute of Allergy and Infectious Diseases Workshop on understanding HIV-exposed but seronegative individuals. AIDS Res Hum Retroviruses. 2011;27:737–743. - PMC - PubMed
1. Horton RE, McLaren PJ, Fowke K, Kimani J, Ball TB. Cohorts for the study of HIV-1-exposed but uninfected individuals: benefits and limitations. J Infect Dis. 2010;202 (Suppl 3):S377–381. - PubMed
1. Miyazawa M, Lopalco L, Mazzotta F, Lo Caputo S, Veas F, Clerici M. The ‘immunologic advantage’ of HIV-exposed seronegative individuals. AIDS (London, England) 2009;23:161–175. - PubMed

Publication types

Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Other Literature Sources
- The Lens - Patent Citations Database
- scite Smart Citations
Medical
- MedlinePlus Health Information

[1] Ranki A, Mattinen S, Yarchoan R, Broder S, Ghrayeb J, Lahdevirta J, Krohn K. T-cell response towards HIV in infected individuals with and without zidovudine therapy, and in HIV-exposed sexual partners. AIDS (London, England) 1989;3:63–69. - PubMed

[2] Ranki A, Mattinen S, Yarchoan R, Broder S, Ghrayeb J, Lahdevirta J, Krohn K. T-cell response towards HIV in infected individuals with and without zidovudine therapy, and in HIV-exposed sexual partners. AIDS (London, England) 1989;3:63–69. - PubMed

[3] Imagawa DT, Lee MH, Wolinsky SM, Sano K, Morales F, Kwok S, Sninsky JJ, Nishanian PG, Giorgi J, Fahey JL, et al. Human immunodeficiency virus type 1 infection in homosexual men who remain seronegative for prolonged periods. N Engl J Med. 1989;320:1458–1462. - PubMed

[4] Imagawa DT, Lee MH, Wolinsky SM, Sano K, Morales F, Kwok S, Sninsky JJ, Nishanian PG, Giorgi J, Fahey JL, et al. Human immunodeficiency virus type 1 infection in homosexual men who remain seronegative for prolonged periods. N Engl J Med. 1989;320:1458–1462. - PubMed

[5] Young JM, Turpin JA, Musib R, Sharma OK. Outcomes of a National Institute of Allergy and Infectious Diseases Workshop on understanding HIV-exposed but seronegative individuals. AIDS Res Hum Retroviruses. 2011;27:737–743. - PMC - PubMed

[6] Young JM, Turpin JA, Musib R, Sharma OK. Outcomes of a National Institute of Allergy and Infectious Diseases Workshop on understanding HIV-exposed but seronegative individuals. AIDS Res Hum Retroviruses. 2011;27:737–743. - PMC - PubMed

[7] Horton RE, McLaren PJ, Fowke K, Kimani J, Ball TB. Cohorts for the study of HIV-1-exposed but uninfected individuals: benefits and limitations. J Infect Dis. 2010;202 (Suppl 3):S377–381. - PubMed

[8] Horton RE, McLaren PJ, Fowke K, Kimani J, Ball TB. Cohorts for the study of HIV-1-exposed but uninfected individuals: benefits and limitations. J Infect Dis. 2010;202 (Suppl 3):S377–381. - PubMed

[9] Miyazawa M, Lopalco L, Mazzotta F, Lo Caputo S, Veas F, Clerici M. The ‘immunologic advantage’ of HIV-exposed seronegative individuals. AIDS (London, England) 2009;23:161–175. - PubMed

[10] Miyazawa M, Lopalco L, Mazzotta F, Lo Caputo S, Veas F, Clerici M. The ‘immunologic advantage’ of HIV-exposed seronegative individuals. AIDS (London, England) 2009;23:161–175. - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Mucosal correlates of protection in HIV-1-exposed sero-negative persons

Affiliation

Mucosal correlates of protection in HIV-1-exposed sero-negative persons

Authors

Affiliation

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical