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Randomized Controlled Trial
. 2014 May;165(4):552-5.
doi: 10.1111/bjh.12739. Epub 2014 Jan 15.

Outcome of Down syndrome associated acute lymphoblastic leukaemia treated on a contemporary protocol

Katharine Patrick  1 , Rachel Wade, Nicholas Goulden, Clare Rowntree, Rachael Hough, Anthony V Moorman, Christopher D Mitchell, Ajay Vora
Affiliations
Randomized Controlled Trial

Outcome of Down syndrome associated acute lymphoblastic leukaemia treated on a contemporary protocol

Katharine Patrick et al. Br J Haematol. 2014 May.

Abstract

We report the outcome for children and young people with Down syndrome-associated acute lymphoblastic leukaemia (DS-ALL) treated on a contemporary protocol. Compared with non-DS ALL, patients with DS-ALL had an inferior event-free survival (65·6% vs. 87·7% at 5 years; P < 0·00005) and overall survival (70·0% vs. 92·2%; P < 0·00005). Excess treatment-related mortality - was primarily responsible for the worse outcomes for DS-ALL (21·6% at 5 years, vs. 3·3%, P < 0·00005). Minimal residual disease (MRD) risk status was highly discriminant for relapse in DS patients with 0/28 relapses in the MRD low risk group.

Keywords: Down syndrome; lymphoblastic leukaemia; treatment.

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