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Case Reports
. 2014 Jan 15:2014:bcr2013009905.
doi: 10.1136/bcr-2013-009905.

Kyrle's disease

Arzu Ataseven  1 , Perihan Ozturk, Iknur Kucukosmanoglu, Gulcan Saylam Kurtipek
Affiliations
Case Reports

Kyrle's disease

Arzu Ataseven et al. BMJ Case Rep. .

Abstract

Kyrle's disease (KD) is a dermatosis which was first described by Kyrle as "hyperkeratosis follicularis et parafollicularis in cutem penetrans" in 1916. Perforating dermatoses are a heterogeneous disorder group characterised by transepithelial elimination. KD has been seen in association with multiple disorders, including diabetes mellitus, renal and liver diseases, congestive heart failure, hyperlipidaemia, infective diseases and abnormal metabolism of vitamin A. This case report presents two patients with KD with associated systemic disease.

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Figures

Figure 1
Figure 1
(A) Erythematous papules exhibiting a central depression with keratotic plug are located on the extensor surfaces of the knees and shins. (B) A close-up image of papules. (C) Epidermal invagination into the dermis, degenerated basophilic material and plug formation were noteworthy in the specimen. H&E staining ×40.
Figure 2
Figure 2
(A) Erythematous papules exhibiting a central depression with keratotic plug are located on the extensor surfaces of the shins. (B) A close-up image of papules. (C) Vacuolar degeneration of the epidermis and suppurated inflammation. H&E staining ×200.
See this image and copyright information in PMC

References

    1. Kyrle J. Hyperkeratosis follicularis et parafollicularis in cutem penetrans. Arch Dermatol Syph 1916;123:466–93
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    1. Schreml S, Hafner C, Eder F, et al. Kyrle disease and acquired perforating collagenosis secondary to chronic renal failure and diabetes mellitus. Case Rep Dermatol 2011;3:209–11 - PMC - PubMed
    1. Lee SJ, Jang JW, Lee WC, et al. Perforating disorder caused by salt-water application and its experimental induction. Int J Dermatol 2005;44:210–14 - PubMed

Publication types

Supplementary concepts