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Review
. 2014 Mar;75(3):376-80.
doi: 10.1038/pr.2013.238. Epub 2013 Dec 12.

Intermittent or sustained systemic inflammation and the preterm brain

Olaf Dammann  1 , Alan Leviton  2
Affiliations
Review

Intermittent or sustained systemic inflammation and the preterm brain

Olaf Dammann et al. Pediatr Res. 2014 Mar.

Abstract

Exposure to perinatal infection and inflammation is associated with an increased risk for neonatal brain damage and developmental disabilities. In this integrated mechanism review, we discuss evidence in support of the contention that the preterm newborn is capable of intermittent or sustained systemic inflammation (ISSI), which appears to contribute more to adverse neurodevelopmental outcomes in preterm infants than does shorter duration inflammation.

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Figures

Figure 1
Figure 1
Proposed list of candidate mechanisms linking infectious and non-infectious stimuli, the initial inflammatory response, and subsequent intermittent or sustained systemic inflammation (ISSI).
See this image and copyright information in PMC

References

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