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. 2014 Apr;52(4):1213-6.
doi: 10.1128/JCM.00031-14. Epub 2014 Jan 15.

Influence of Acanthamoeba genotype on clinical course and outcomes for patients with Acanthamoeba keratitis in Spain

Francisco Arnalich-Montiel  1 , Blanca Lumbreras-Fernández, Carmen M Martín-Navarro, Basilio Valladares, Rogelio Lopez-Velez, Rafael Morcillo-Laiz, Jacob Lorenzo-Morales
Affiliations

Influence of Acanthamoeba genotype on clinical course and outcomes for patients with Acanthamoeba keratitis in Spain

Francisco Arnalich-Montiel et al. J Clin Microbiol. 2014 Apr.

Abstract

Genotype T4 is by far the most frequent genotype of Acanthamoeba keratitis (AK) and therefore has been considered the most virulent. This study included 14 cases of AK of genotype T4 and three cases of non-T4 genotype. We found that cases of non-T4 genotype had a worse response to medical therapy, greater need for surgical intervention, greater risk of extracorneal involvement, and remarkably poorer final visual outcome than those of T4 genotype, suggesting an association between Acanthamoeba virulence and genotype that requires additional case investigation.

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