Oral Hypoglycemic Agents in pregnancy: An Update

doi:10.1007/s13224-012-0312-z

Review

. 2013 Apr;63(2):82-7.

doi: 10.1007/s13224-012-0312-z. Epub 2013 Mar 27.

Oral Hypoglycemic Agents in pregnancy: An Update

Nagandla Kavitha¹, Somsubhra De¹, Sachchithanantham Kanagasabai¹

Affiliations

PMID: 24431611
PMCID: PMC3664692
DOI: 10.1007/s13224-012-0312-z

Review

Oral Hypoglycemic Agents in pregnancy: An Update

Nagandla Kavitha et al. J Obstet Gynaecol India. 2013 Apr.

. 2013 Apr;63(2):82-7.

doi: 10.1007/s13224-012-0312-z. Epub 2013 Mar 27.

Authors

Nagandla Kavitha¹, Somsubhra De¹, Sachchithanantham Kanagasabai¹

Affiliation

¹ Department of Obstetrics and Gynecology, Melaka Manipal Medical College, Jalan Batu Hampar, 75150 Bukit Baru, Melaka Malaysia.

PMID: 24431611
PMCID: PMC3664692
DOI: 10.1007/s13224-012-0312-z

Abstract

Introduction: Traditionally, insulin has been the gold standard in the management of Type 2 diabetes in pregnancy and gestational diabetes. However, insulin therapy can be inconvenient because of the needs for multiple injections, its associated cost, pain at the injection site, need for refrigeration, and skillful handling of the syringes. This has led to the exploration of oral hypoglycemic agents as an alternative to insulin therapy.

Objectives: This review examines and evaluates the evidences on the efficacy, safety, and current recommendations of oral hypoglycemic agents.

Conclusion: The evidence of this study supports the use of glyburide and metformin in the management of Type 2 diabetes and gestational diabetes with no increased risk of neonatal hypoglycemia or congenital anomalies. The safety of these oral hypoglycemic agents are limited to the prenatal period and more randomized controlled trials are required to provide information on the long-term follow up on neonatal and cognitive development.

Keywords: Gestational diabetes mellitus; Oral hypoglycemic agents; Type 2 diabetes.

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References

1. Jovanovic L, Pettitt DJ. Gestational diabetes mellitus. JAMA. 2001;286(20):2516–2518. doi: 10.1001/jama.286.20.2516. - DOI - PubMed
1. Sheffield JS, Butler-Koster EL, Casey BM, et al. Maternal diabetes mellitus and infant malformations. Obstet Gynecol. 2002;100(5 pt 1):925–930. doi: 10.1016/S0029-7844(02)02242-1. - DOI - PubMed
1. Ferrara A, Kahn H, Quesenberry CP, et al. An increase in the incidence of gestational diabetes mellitus: Northern California. Obstet Gynecol. 2004;103:526–533. doi: 10.1097/01.AOG.0000113623.18286.20. - DOI - PubMed
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1. Langer O. Management of gestational diabetes. Clin Obstet Gynecol. 2000;43:106–115. doi: 10.1097/00003081-200003000-00011. - DOI - PubMed

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[1] Jovanovic L, Pettitt DJ. Gestational diabetes mellitus. JAMA. 2001;286(20):2516–2518. doi: 10.1001/jama.286.20.2516. - DOI - PubMed

[2] Jovanovic L, Pettitt DJ. Gestational diabetes mellitus. JAMA. 2001;286(20):2516–2518. doi: 10.1001/jama.286.20.2516. - DOI - PubMed

[3] Sheffield JS, Butler-Koster EL, Casey BM, et al. Maternal diabetes mellitus and infant malformations. Obstet Gynecol. 2002;100(5 pt 1):925–930. doi: 10.1016/S0029-7844(02)02242-1. - DOI - PubMed

[4] Sheffield JS, Butler-Koster EL, Casey BM, et al. Maternal diabetes mellitus and infant malformations. Obstet Gynecol. 2002;100(5 pt 1):925–930. doi: 10.1016/S0029-7844(02)02242-1. - DOI - PubMed

[5] Ferrara A, Kahn H, Quesenberry CP, et al. An increase in the incidence of gestational diabetes mellitus: Northern California. Obstet Gynecol. 2004;103:526–533. doi: 10.1097/01.AOG.0000113623.18286.20. - DOI - PubMed

[6] Ferrara A, Kahn H, Quesenberry CP, et al. An increase in the incidence of gestational diabetes mellitus: Northern California. Obstet Gynecol. 2004;103:526–533. doi: 10.1097/01.AOG.0000113623.18286.20. - DOI - PubMed

[7] Beischer NA, Oats J, Henry OA, et al. Incidence and severity of gestational diabetes mellitus according to country of birth in women living in Australia. Diabetes Care. 1991;40(Suppl. 2):35–38. - PubMed

[8] Beischer NA, Oats J, Henry OA, et al. Incidence and severity of gestational diabetes mellitus according to country of birth in women living in Australia. Diabetes Care. 1991;40(Suppl. 2):35–38. - PubMed

[9] Langer O. Management of gestational diabetes. Clin Obstet Gynecol. 2000;43:106–115. doi: 10.1097/00003081-200003000-00011. - DOI - PubMed

[10] Langer O. Management of gestational diabetes. Clin Obstet Gynecol. 2000;43:106–115. doi: 10.1097/00003081-200003000-00011. - DOI - PubMed

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Oral Hypoglycemic Agents in pregnancy: An Update

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Oral Hypoglycemic Agents in pregnancy: An Update

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