[Clinicopathologic characteristics of sporadic renal hemangioblastoma]

Abstract

Objective: To investigate the clinicopathological characteristics of sporadic renal hemangioblastoma.

Methods: Two cases of sporadic renal hemangioblastoma were studied by histological and immunohistochemical staining, along with review of the literature.

Results: Both cases were presented with a renal mass during annual physical examination with an age of 40 and 45 years, respectively. The lesions located in the middle portion of the kidney with a sharp tumor border. Histopathologically, the tumors were characterized by two major components: capillary and stromal cells. Immunohistochemically, the stromal cells were positive for vimentin, NSE, S-100 protein and inhibin-α, and negative for CK, HMB45, Melan A, EMA, CD56 and syn. Both tumors showed a very low level of Ki-67 labeling. The endothelial cells were positive for CD34.

Conclusion: Sporadic renal hemangioblastoma is a rare benign neoplasm, the diagnosis of which is based on the characteristic follicular architecture and an exclusion of other carcinomas of the kidney.