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Comment
. 2014 Feb 11;111(6):2058-9.
doi: 10.1073/pnas.1323183111. Epub 2014 Jan 16.

Microbial metabolites control gut inflammatory responses

Nicholas Arpaia  1 , Alexander Y Rudensky
Affiliations
Comment

Microbial metabolites control gut inflammatory responses

Nicholas Arpaia et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Multiple bacterial species and microbial metabolites shape immunity in the intestines. (A) Colonization by SFB or delivery of bacterial-derived ATP promotes Th17 induction by unknown and indirect mechanisms involving DCs. (B) Clostridia species, via production of SCFA, promote the proliferation (i) and de novo induction (ii) of Treg cells in the colonic lamina propria via distinct mechanisms. (C) HDAC inhibitory activity of n-butyrate suppresses proinflammatory cytokine production by intestinal macrophages (MΦ).
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