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Review
. 2014 Mar;36(2):137-48.
doi: 10.1007/s00281-013-0409-1. Epub 2014 Jan 17.

From proliferation to proliferation: monocyte lineage comes full circle

Filip K Swirski  1 , Ingo Hilgendorf, Clinton S Robbins
Affiliations
Review

From proliferation to proliferation: monocyte lineage comes full circle

Filip K Swirski et al. Semin Immunopathol. 2014 Mar.

Abstract

Monocytes are mononuclear circulating phagocytes that originate in the bone marrow and give rise to macrophages in peripheral tissue. For decades, our understanding of monocyte lineage was bound to a stepwise model that favored an inverse relationship between cellular proliferation and differentiation. Sophisticated molecular and surgical cell tracking tools have transformed our thinking about monocyte topo-ontogeny and function. Here, we discuss how recent studies focusing on progenitor proliferation and differentiation, monocyte mobilization and recruitment, and macrophage differentiation and proliferation are reshaping knowledge of monocyte lineage in steady state and disease.

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Figures

Figure 1
Figure 1
The topo-ontogenic relationships in the monocyte lineage. The figure shows the development of monocytes in the bone marrow and extramedullary sites from hematopoietic precursors, their circulation in the blood, and differentiation and proliferation in tissue.
See this image and copyright information in PMC

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