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Editorial
. 2014 Jan 17;114(2):230-2.
doi: 10.1161/CIRCRESAHA.113.302971.

Contribution of extramedullary organs in myocardial inflammation and remodeling: does the spleen cause cardiac melancholy?

Nikolaos G Frangogiannis  1
Affiliations
Editorial

Contribution of extramedullary organs in myocardial inflammation and remodeling: does the spleen cause cardiac melancholy?

Nikolaos G Frangogiannis. Circ Res. .
No abstract available

Keywords: Editorials; bone marrow; inflammation; monocytes; spleen; ventricular remodeling.

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Figures

Figure
Figure
The bone marrow and extramedullary sources contribute monocytes that regulate the inflammatory and remodeling response in the infarcted heart. Chemokine-driven pathways may be responsible for recruitment of bone marrow monocytes. A growing body of evidence suggests the involvement of the splenic monocyte reservoir in myocardial inflammation and remodeling. The spleen may contribute Ly6Chi monocytes during the inflammatory phase of infarct healing. Moreover, during the chronic remodeling phase, poorly characterized subsets of mononuclear splenocytes (Mo Sp), mobilized through neurohumoral pathways, may home to the myocardium and may be involved in the pathogenesis of heart failure (WP, white pulp; RP, red pulp).
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References

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