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. 2013 Jun;74(3):118-25.
doi: 10.1055/s-0033-1347358. Epub 2013 May 15.

Adenoid cystic carcinoma of the nasal cavity and paranasal sinuses: a meta-analysis

Moran Amit  1 , Yoav Binenbaum  1 , Kanika Sharma  2 , Naomi Ramer  3 , Ilana Ramer  4 , Abib Agbetoba  5 , Brett Miles  5 , Xinjie Yang  6 , Delin Lei  6 , Kristine Bjoerndal  7 , Christian Godballe  7 , Thomas Mücke  8 , Klaus-Dietrich Wolff  8 , Dan Fliss  9 , André M Eckardt  10 , Chiara Copelli  11 , Enrico Sesenna  11 , Frank Palmer  12 , Snehal Patel  12 , Ziv Gil  1
Affiliations

Adenoid cystic carcinoma of the nasal cavity and paranasal sinuses: a meta-analysis

Moran Amit et al. J Neurol Surg B Skull Base. 2013 Jun.

Erratum in

  • J Neurol Surg B Skull Base. 2014 Jun;75(3):e1. Naomi, Ramer [corrected to Ramer, Naomi]; Ilana, Ramer [corrected to Ramer, Ilana]; Abib, Agbetoba [corrected to Agbetoba, Abib]; Kristine, Bjoerndal [corrected to Bjoerndal, Kristine]; Christian, Godballe [corrected to Godballe,Christian]; Thomas, Mücke
  • Erratum: adenoid cystic carcinoma of the nasal cavity and paranasal sinuses: a meta-analysis.
    Amit M, Binenbaum Y, Sharma K, Ramer N, Ramer I, Agbetoba A, Miles B, Yang X, Lei D, Bjoerndal K, Godballe C, Mücke T, Wolff KD, Fliss D, Eckardt AM, Copelli C, Sesenna E, Palmer F, Patel S, Gil Z. Amit M, et al. J Neurol Surg B Skull Base. 2014 Jun;75(3):e1. doi: 10.1055/s-0034-1372486. J Neurol Surg B Skull Base. 2014. PMID: 24967153 Free PMC article. No abstract available.

Abstract

Objectives To identify independent predictors of outcome in patients with adenoid cystic carcinoma (ACC) of the paranasal sinuses and skull base. Design Meta-analysis of the literature and data from the International ACC Study Group. Setting University-affiliated medical center. Participants The study group consisted of 520 patients, 99 of them from the international cohort. The median follow-up period was 60 months (range, 32 to 100 months). Main Outcome Measures Overall survival (OS) and disease-specific survival (DSS). Results The 5-year OS and DSS of the entire cohort were 62% and 67%, respectively. The local recurrence rate was 36.6%, and the regional recurrence rate was 7%. Distant metastasis, most commonly present in the lung, was recorded in 106 patients (29.1%). In the international cohort, positive margins and ACC of the sphenoid or ethmoidal sinuses were significant predictors of outcome (p < 0.001). Perineural invasion and adjuvant treatment (radiotherapy or chemoradiation) were not associated with prognosis. Conclusion Tumor margin status and tumor site are associated with prognosis in ACC of the paranasal sinuses, whereas perineural invasion is not. Adjuvant treatment apparently has no impact on outcome.

Keywords: adenoid cystic carcinoma; meta analysis; paranasal sinuses; skull base; survival.

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Figures

Fig. 1
Fig. 1
Flowchart of the study selection process. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement.
Fig. 2
Fig. 2
Survival rates in the included studies. (A) 5-year overall survival. (B) 5-year disease-specific survival. (C) 5-year disease-free survival. The dashed line indicates the mean survival rate for the whole group. *Only the sphenoid sinus is involved. †Only the maxillary sinus is involved. ‡Only the nasopharynx is involved.
Fig. 3
Fig. 3
Kaplan-Meier 5-year disease-specific survival analysis. (A) Site of tumor. (B) Perineural invasion status. (C) Tmor margin status. (D) Treatment group. *Only the sphenoid sinus is involved. †Only the maxillary sinus is involved. ‡Only the nasopharynx is involved. Data are not provided.
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