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Case Reports
. 1987 Oct 10;2(8563):827-8.
doi: 10.1016/s0140-6736(87)91016-6.

Inhibition of HIV replication in vitro by fusidic acid

V Faber  1 , A G Dalgleish, A Newell, M Malkovsky
Affiliations
Case Reports

Inhibition of HIV replication in vitro by fusidic acid

V Faber et al. Lancet. .

Abstract

A 58-year-old man with AIDS improved clinically after the introduction of fusidic acid, 500 mg three times a day orally, to his therapeutic regimen. Fusidic acid may have had a direct effect against HIV. Fusidic acid has anti-HIV activity in vitro at levels readily attainable in vivo. The drug does not appear to be a reverse transcriptase inhibitor and its mode of action against HIV is unknown. Fusidic acid can be given orally and has few side-effects. These results justify fuller evaluation of fusidic acid as therapy against AIDS and HIV infection.

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