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. 1987;19(4):449-56.

[Importance of calcium ions and impulse activity for neurotrophic control of the membrane potential of muscle fibers in the rat]

[Article in Russian]
A Kh Urazaev, A V Chikin, E M Volkov, G I Poletaev, Kh S Khamitov
  • PMID: 2443859

[Importance of calcium ions and impulse activity for neurotrophic control of the membrane potential of muscle fibers in the rat]

[Article in Russian]
A Kh Urazaev et al. Neirofiziologiia. 1987.

Abstract

The blockade of the Ca++ influx increased the postdenervation depolarization of the membrane potential in rat diaphragm muscle fibres, while elevation of the intracellular Ca++ content by caffeine hyperpolarized the muscle membrane. Direct electrical stimulation of muscle or application of carbamylcholine reduced the degree of postdenervation membrane depolarization. Verapamil and d-tubocurarine abolished the hyperpolarizing effect of the electrical stimulation. The hyperpolarizing effects of carbamylcholine and electrical stimulation were not added. It is suggested that the influx of the extracellular Ca++ through acetylcholine-sensitive ionic channels in the external muscle membrane contributes to the neurotrophic regulation of the membrane potential in rat muscle fibres.

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