GPR109a: the missing link between microbiome and good health?
- PMID: 24439263
- PMCID: PMC4337780
- DOI: 10.1016/j.immuni.2013.12.009
GPR109a: the missing link between microbiome and good health?
Abstract
A complex partnership between the host and the vast intestinal microbial ecosystem serves numerous biological activities including nutrition, immunity, and barrier function. In this issue of Immunity, Singh et al. (2014) demonstrate that microbial-derived butyrate mediated its protective activity against inflammation and colorectal cancer through GPR109a signaling.
Copyright © 2014 Elsevier Inc. All rights reserved.
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Comment on
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Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis.Immunity. 2014 Jan 16;40(1):128-39. doi: 10.1016/j.immuni.2013.12.007. Epub 2014 Jan 9. Immunity. 2014. PMID: 24412617 Free PMC article.
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