The shape of things to come
- PMID: 24439365
- DOI: 10.1016/j.cell.2013.12.037
The shape of things to come
Abstract
Surface receptors can link binding of ligands to changes in the actin-based cell cytoskeleton. Chia et al. and Chen et al. provide evidence for direct binding between the cytoplasmic tails of receptors and the WAVE complex, a regulator of the actin nucleator Arp2/3 complex, which might help to explain how environmental signals are translated into changes in morphology and motility.
Copyright © 2014 Elsevier Inc. All rights reserved.
Comment on
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The WAVE regulatory complex links diverse receptors to the actin cytoskeleton.Cell. 2014 Jan 16;156(1-2):195-207. doi: 10.1016/j.cell.2013.11.048. Cell. 2014. PMID: 24439376 Free PMC article.
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Local F-actin network links synapse formation and axon branching.Cell. 2014 Jan 16;156(1-2):208-20. doi: 10.1016/j.cell.2013.12.009. Cell. 2014. PMID: 24439377 Free PMC article.
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