Tumor antigenicity revealed
- PMID: 24439426
- PMCID: PMC3932747
- DOI: 10.1016/j.it.2014.01.001
Tumor antigenicity revealed
Abstract
The extent to which mutated peptide antigens encoded by somatic mutations contribute to tumor antigenicity in human cancer patients has been unclear. Two recent studies using tumor exome sequencing to predict candidate mutated antigens provide insight into this question.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Comment on
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Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells.Nat Med. 2013 Jun;19(6):747-52. doi: 10.1038/nm.3161. Epub 2013 May 5. Nat Med. 2013. PMID: 23644516 Free PMC article.
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Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma.J Clin Oncol. 2013 Nov 10;31(32):e439-42. doi: 10.1200/JCO.2012.47.7521. Epub 2013 Sep 16. J Clin Oncol. 2013. PMID: 24043743 Free PMC article. No abstract available.
References
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- Page DB, Postow MA, Callahan MK, Allison JP, Wolchok JD. Immune Modulation in Cancer with Antibodies. Annual review of medicine. 2013 Oct 30; - PubMed
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