Mycobacterial lipid logic

M Sloan Siegrist¹, Carolyn R Bertozzi²

Affiliations

¹ Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
² Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: crb@berkeley.edu.

PMID: 24439891
PMCID: PMC4123792
DOI: 10.1016/j.chom.2013.12.005

Comment

Mycobacterial lipid logic

M Sloan Siegrist et al. Cell Host Microbe. 2014.

. 2014 Jan 15;15(1):1-2.

doi: 10.1016/j.chom.2013.12.005.

Authors

M Sloan Siegrist¹, Carolyn R Bertozzi²

Affiliations

¹ Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
² Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: crb@berkeley.edu.

PMID: 24439891
PMCID: PMC4123792
DOI: 10.1016/j.chom.2013.12.005

Abstract

During infection of the lung epithelium, Mycobacterium tuberculosis must infect and survive within macrophages long enough to be transported into deeper lung tissues. Cambier et al. (2013) show that pathogenic mycobacteria use the coordinated action of two cell wall glycolipids to regulate macrophage recruitment to initial infection sites.

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Figures

**Figure 1. Mycobacterial Cell Wall Lipids Modulate Macrophage Composition at the Earliest Sites of Infection**
PDIM suppresses the recruitment of microbicidal, iNOS-positive macrophages by inhibiting TLR signaling, while PGL stimulates the recruitment of more permissive, iNOS-negative macrophages via the CCR2 pathway.

See this image and copyright information in PMC

Comment on

Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids.
Cambier CJ, Takaki KK, Larson RP, Hernandez RE, Tobin DM, Urdahl KB, Cosma CL, Ramakrishnan L. Cambier CJ, et al. Nature. 2014 Jan 9;505(7482):218-22. doi: 10.1038/nature12799. Epub 2013 Dec 15. Nature. 2014. PMID: 24336213 Free PMC article.

References

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1. Cambier CJ, Takaki KK, Larson RP, Hernandez RE, Tobin DM, Urdahl KB, Cosma CL, Ramakrishnan L. [Published online December 15, 2013];Nature. 2013 http://dx.doi.org/10.1038/nature12799. - DOI - PMC - PubMed
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Mycobacterial lipid logic

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Mycobacterial lipid logic

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