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Review
. 2014 Feb:18:46-54.
doi: 10.1016/j.cbpa.2013.12.009. Epub 2014 Jan 16.

DNA directed immobilization glycocluster array: applications and perspectives

Yann Chevolot  1 , Emmanuelle Laurenceau  2 , Magali Phaner-Goutorbe  2 , Virginie Monnier  2 , Eliane Souteyrand  2 , Albert Meyer  3 , Thomas Géhin  2 , Jean-Jacques Vasseur  3 , François Morvan  4
Affiliations
Review

DNA directed immobilization glycocluster array: applications and perspectives

Yann Chevolot et al. Curr Opin Chem Biol. 2014 Feb.

Abstract

The present review concerns the recent advances in DNA directed immobilization (DDI) based glycocluster array. The impact of glycan immobilization on subsequent interactions with protein is discussed and the consequent pros and cons of DDI-based glycocluster array are reviewed. Finally, application in the discovery of anti-pathogen molecules is illustrated by screening for galactose or fucose glycoclusters targeting two Pseudomonas aeruginosa virulence factors (PA-IL and PA-IIL).

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