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Comment
. 2014 May;40(3):499-500.
doi: 10.1093/schbul/sbt237. Epub 2014 Jan 17.

ZNF804A protein is widely expressed in human brain neurons: possible implications on normal brain structure and pathomorphologic changes in schizophrenia

Hans-Gert Bernstein  1 , Johann Steiner, Henrik Dobrowolny, Bernhard Bogerts
Affiliations
Comment

ZNF804A protein is widely expressed in human brain neurons: possible implications on normal brain structure and pathomorphologic changes in schizophrenia

Hans-Gert Bernstein et al. Schizophr Bull. 2014 May.
No abstract available

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Figures

Fig. 1.
Fig. 1.
Immunohistochemical demonstration of ZNF 804A in adult and developing human brain. (A) Temporal cortex of a 49 years old male. TNF 804A is expressed in layer III pyramidal cells and interneurons. (B) Cerebellum of a 55 years old female. A vast majority of granule cells and a few Purkinje cells were found to express the protein. (C) ZNF 804A expression in the cortex anlage of a fetal brain (19th gestational week). Multiple neuroblasts and radial glial cells are intensely immunostained. Scale Bars (valid for figures 1A–C) = 25 µm.
See this image and copyright information in PMC

Comment on

  • ZNF804A and cortical structure in schizophrenia: in vivo and postmortem studies.
    Schultz CC, Nenadic I, Riley B, Vladimirov VI, Wagner G, Koch K, Schachtzabel C, Mühleisen TW, Basmanav B, Nöthen MM, Deufel T, Kiehntopf M, Rietschel M, Reichenbach JR, Cichon S, Schlösser RG, Sauer H. Schultz CC, et al. Schizophr Bull. 2014 May;40(3):532-41. doi: 10.1093/schbul/sbt123. Epub 2013 Sep 27. Schizophr Bull. 2014. PMID: 24078172 Free PMC article.

References

    1. Schultz CC, Nenadic I, Riley B, et al. ZNF804A and cortical structure in schizophrenia: in vivo and postmortem studies [published online ahead of print September 2008]. Schizophr Bull. 2013 - PMC - PubMed
    1. Hill MJ, Bray NJ. Evidence that schizophrenia risk variation in the ZNF804A gene exerts its effects during fetal brain development. Am J Psychiatry. 2012;169:1301–1308 - PubMed
    1. Hill MJ, Jeffries AR, Dobson RJ, Price J, Bray NJ. Knockdown of the psychosis susceptibility gene ZNF804A alters expression of genes involved in cell adhesion. Hum Mol Genet. 2012;21:1018–1024 - PubMed
    1. Bernstein HG, Stricker R, Dobrowolny H, et al. Nardilysin in human brain diseases: both friend and foe. Amino Acids. 2013;45:269–278 - PubMed

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