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. 1987 Sep 2;141(1):139-41.
doi: 10.1016/0014-2999(87)90421-3.

Pinacidil increases the background potassium current in single ventricular cells

T Iijima  1 , N Taira
Affiliations

Pinacidil increases the background potassium current in single ventricular cells

T Iijima et al. Eur J Pharmacol. .

Abstract

Pinacidil, a new antihypertensive agent, increased the background (inward rectifier) potassium current and abolished its negative slope, and did not change the time-dependent component of the outward (delayed outward) current in single ventricular cells isolated from the guinea-pig heart. These effects must be responsible for the negative inotropic action of this drug.

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