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. 2014 Apr;11(4):663-9.
doi: 10.1016/j.hrthm.2014.01.018. Epub 2014 Jan 18.

Relations between circulating microRNAs and atrial fibrillation: data from the Framingham Offspring Study

David D McManus  1 , Honghuang Lin  2 , Kahraman Tanriverdi  3 , Michael Quercio  4 , Xiaoyan Yin  5 , Martin G Larson  6 , Patrick T Ellinor  7 , Daniel Levy  8 , Jane E Freedman  3 , Emelia J Benjamin  9
Affiliations

Relations between circulating microRNAs and atrial fibrillation: data from the Framingham Offspring Study

David D McManus et al. Heart Rhythm. 2014 Apr.

Abstract

Background: MicroRNA (miRNA) expression in atrial tissue has been implicated in pathologic susceptibility to atrial fibrillation (AF). Nevertheless, data on how circulating levels relate to AF are limited.

Objective: The purpose of this study was to test the hypothesis that circulating miRNAs are associated with AF.

Methods: Among 2445 Framingham Heart Study Offspring participants, we measured the expression of 385 circulating whole blood miRNAs by high-throughput quantitative reverse transcriptase polymerase chain reaction. We related miRNA levels with prevalent and new-onset AF.

Results: Mean age of the cohort was 66.3 ± 8.9 years, and 56% were women; 153 participants had clinically apparent AF at baseline, and 107 developed AF during median follow-up of 5.4 years. miRNA-328 (miR-328) expression was lower among participants with prevalent AF (8.76 cycle threshold) compared to individuals with no AF (7.75 cycle threshold, P <.001). The association between miR-328 and prevalent AF persisted after adjustment for age, sex, and technical covariates (odds ratio 1.21, P = 1.8 × 10(-4)) but was attenuated in analyses adjusting for clinical AF risk factors (odds ratio 1.14, P = .017). In contrast to the associations between miR-328 and prevalent AF, none of the circulating miRNAs were associated with incident AF.

Conclusion: Circulating levels of miR-328, a miRNA known to promote atrial electrical remodeling by reducing L-type Ca(2+) channel density, were associated with prevalent AF. Adjustment for risk factors that promote atrial remodeling, including hypertension, attenuated the association between miR-328 and AF, potentially implicating miR-328 as a potential mediator of atrial remodeling and AF vulnerability.

Keywords: Atrial fibrillation; Circulation; Epidemiology; Risk factors; microRNA.

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Figures

Figure 1
Figure 1
MicroRNA-328 Expression in Prevalent Atrial Fibrillation (AF) vs. those with No Atrial Fibrillation
See this image and copyright information in PMC

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