Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Sep 23;141(3):519-22.
doi: 10.1016/0014-2999(87)90578-4.

Mu-opioid receptors modulate non-cholinergic constrictor nerves in guinea-pig airways

N Frossard  1 , P J Barnes
Affiliations

Mu-opioid receptors modulate non-cholinergic constrictor nerves in guinea-pig airways

N Frossard et al. Eur J Pharmacol. .

Abstract

A role of opioids as inhibitors of the non-adrenergic non-cholinergic (NANC) excitatory nerves has been studied in the guinea-pig bronchi using electrical field stimulation. Morphine and DAGO gave dose-dependent inhibition of NANC contraction, which was reversed by naloxone, whereas the cholinergic nerve and substance P responses were unaffected. [Met5]enkephalin and [Leu5]enkephalin weakly inhibited NANC contraction, whereas dynorphin-(1-13) had no effect. These results suggest that opiates inhibit NANC bronchoconstriction via mu-opioid receptors.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources