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. 2014 Jul;33(7):731-3.
doi: 10.1097/INF.0000000000000268.

Clinical evaluation of vancomycin dosage in pediatric oncology patients

Stefan J W J Sanders  1 , Yuma A Bijleveld, Fleur Sinkeler, Elles M Kemper, Dasja Pajkrt, Marianne van de Wetering, Natasha K A van Eijkelenburg, Ron A A Mathôt
Affiliations

Clinical evaluation of vancomycin dosage in pediatric oncology patients

Stefan J W J Sanders et al. Pediatr Infect Dis J. 2014 Jul.

Abstract

Vancomycin trough serum concentrations were below therapeutic range (8-15 mg/L) in 58% of 124 pediatric oncology patients receiving 60 mg/kg/d divided qid. Patients <6 and between 6 and 12 years had significantly lower trough concentrations than patients >12 years. A vancomycin dosage of 60 mg/kg/d is inadequate for pediatric oncology patients >12 years.

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