Serum 25 hydroxy vitamin D insufficiency associated with bronchial asthma in Lucknow, India

Abstract

Objectives: To assess the association between serum 25 hydroxy vitamin D levels and asthma and its control in Indian children.

Methods: This was a prospective case-control study conducted in tertiary care hospital. Cases of asthma and healthy age-matched controls were included, aged 1-15 y, who had not received any vitamin D supplementation in the last year and had no other co-morbidity, after obtaining written informed parental consent. 25 hydroxy vitamin D insufficiency was taken below level of ≤ 30 ng/mL.

Results: Fifty asthmatics and 25 age-matched controls were recruited from August 2011-July 2012. 25 hydroxy vitamin D insufficiency was associated with occurrence of asthma (OR = 13.5; 95 % CI = 4.25-42.85: p = 0.000). With decreasing level of asthma control there was increasing strength of association with 25 hydroxy vitamin D insufficiency [χ (2) for trend = 24.96 (p = 0.000)].

Conclusions: 25 hydroxy vitamin D insufficiency is associated with bronchial asthma as well as its level of control.