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Review
. 2014:805:157-69.
doi: 10.1007/978-3-319-02970-2_7.

Coarse-grained models of the proteins backbone conformational dynamics

Affiliations
Review

Coarse-grained models of the proteins backbone conformational dynamics

Tap Ha-Duong. Adv Exp Med Biol. 2014.

Abstract

Coarse-grained models are more and more frequently used in the studies of the proteins structural and dynamic properties, since the reduced number of degrees of freedom allows to enhance the conformational space exploration. This chapter attempts to provide an overview of the various coarse-grained models that were applied to study the functional conformational changes of the polypeptides main chain around their native state. It will more specifically discuss the methods used to represent the protein backbone flexibility and to account for the physico-chemical interactions that stabilize the secondary structure elements.

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