Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2014 Nov;15(7):502-10.
doi: 10.1111/pedi.12120. Epub 2014 Jan 22.

Cardiovascular health in adolescents with type 1 diabetes: the SEARCH CVD study

Amy C Alman  1 , Jennifer W Talton, R Paul Wadwa, Elaine M Urbina, Lawrence M Dolan, Stephen R Daniels, Richard F Hamman, Ralph B D'Agostino, Santica M Marcovina, Elizabeth J Mayer-Davis, Dana M Dabelea
Affiliations
Multicenter Study

Cardiovascular health in adolescents with type 1 diabetes: the SEARCH CVD study

Amy C Alman et al. Pediatr Diabetes. 2014 Nov.

Abstract

Objective: In their Strategic Impact Goal Statement, the American Heart Association focused on primordial prevention of cardiovascular risk factors by defining metrics for ideal cardiovascular health (ICH). The prevalence of ICH among youth with type 1 diabetes is unknown. Youth with type 1 diabetes face an increased risk of cardiovascular disease (CVD) as they age. The purpose of this report was to examine the prevalence of ICH in a population of youth with type 1 diabetes and to examine the association of ICH with measures of cardiovascular structure and function.

Research design and methods: This report is based on SEARCH CVD an ancillary study to the SEARCH for Diabetes in Youth. A total of 190 adolescents with type 1 diabetes had complete data on all of the ICH metrics at baseline and had measures of arterial stiffness [pulse wave velocity (PWV), brachial distensibility (BrachD), and augmentation index (AIx)] and carotid intima-media thickness completed at a follow-up visit [on average 5 yr after baseline (interquartile range 4-5)].

Results: No subjects met the ICH criteria for all 7 metrics. Meeting an increasing number of ICH metrics was significantly associated with lower arterial stiffness [lower PWV of the trunk (β = -0.02 ±0.01; p = 0.004) and AIx (β = -2.2 ±0.66; p = 0.001), and increased BrachD (β = 0.14 ±0.07; p = 0.04)].

Conclusions: Increasing number of ICH metrics was significantly associated with decreased arterial stiffness, but prevalence of ICH in this population was low. Youth with type 1 diabetes could benefit from improvements in their cardiovascular health.

Keywords: adolescent; carotid intima-media thickness; diabetes mellitus, type 1; pulse wave analysis.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Number of individual ICH metrics met by study participants.
See this image and copyright information in PMC

References

    1. Roger VL, Go AS, Lloyd-Jones DM, et al. Heart Disease and Stroke Statistics--2011 Update: A Report From the American Heart Association. Circulation. 2011;123:e18–e209. - PMC - PubMed
    1. Laing SP, Swerdlow AJ, Slater SD, et al. Mortality from heart disease in a cohort of 23,000 patients with insulin-treated diabetes. Diabetologia. 2003;46:760–5. - PubMed
    1. Forlenza GP, Rewers M. The epidemic of type 1 diabetes: what is it telling us? Current opinion in endocrinology, diabetes, and obesity. 2011;18:248–51. - PubMed
    1. Libby P, Nathan DM, Abraham K, et al. Report of the National Heart, Lung, and Blood Institute-National Institute of Diabetes and Digestive and Kidney Diseases Working Group on Cardiovascular Complications of Type 1 Diabetes Mellitus. Circulation. 2005;111:3489–93. - PubMed
    1. Lloyd-Jones DM, Hong Y, Labarthe D, et al. Defining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association's strategic Impact Goal through 2020 and beyond. Circulation. 2010;121:586–613. - PubMed

Publication types

MeSH terms