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Comparative Study
. 1987 Oct;19(5 Suppl 6):57-61.

Canine kidney transplantation with FK-506 alone or in combination with cyclosporine and steroids

S Todo  1 , A J Demetris, Y Ueda, O Imventarza, K Okuda, A Casavilla, S Cemaj, A Ghalab, V Mazzaferro, B S Rhoe, et al.
Affiliations
Comparative Study

Canine kidney transplantation with FK-506 alone or in combination with cyclosporine and steroids

S Todo et al. Transplant Proc. 1987 Oct.

Abstract

The immunosuppressive agent FK permitted increased kidney transplant survival in dogs over a wide dose range, but with weight loss and manifold evidence of toxicity. The best use of FK at low doses was in combination with CyA and Pred.

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Figures

Fig. 1
Fig. 1
Influence of FK dose on serum creatinine level. The rises in the serum creatinine concentration in animals of all groups were usually caused by rejection.
Fig. 2
Fig. 2
Serum creatinine levels in dogs treated with drug combinations. Note the superior results in group V.
See this image and copyright information in PMC

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References

    1. Ochini T, Nagata M, Nakajima K, et al. Transplantation. 1987 (in press) - PubMed
    1. Todo S, Makowka L, Starzl TE. Surg Res Comm. 1987 (in press) - PMC - PubMed
    1. Ochiai T, Nakajima K, Nagata M, et al. Transplant Proc. 1987;19:1284. - PubMed
    1. Lee P, Murase N, Todo S, et al. Surg Res Comm. 1987 (in press) - PMC - PubMed
    1. Murase N, Lee P, Lei H, et al. Transplant Proc. (this issue)

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