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Comparative Study
. 1987 Oct;19(5 Suppl 6):57-61.

Canine kidney transplantation with FK-506 alone or in combination with cyclosporine and steroids

S Todo  1 , A J Demetris, Y Ueda, O Imventarza, K Okuda, A Casavilla, S Cemaj, A Ghalab, V Mazzaferro, B S Rhoe, et al.
Affiliations
Comparative Study

Canine kidney transplantation with FK-506 alone or in combination with cyclosporine and steroids

S Todo et al. Transplant Proc. 1987 Oct.

Abstract

The immunosuppressive agent FK permitted increased kidney transplant survival in dogs over a wide dose range, but with weight loss and manifold evidence of toxicity. The best use of FK at low doses was in combination with CyA and Pred.

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Figures

Fig. 1
Fig. 1
Influence of FK dose on serum creatinine level. The rises in the serum creatinine concentration in animals of all groups were usually caused by rejection.
Fig. 2
Fig. 2
Serum creatinine levels in dogs treated with drug combinations. Note the superior results in group V.
See this image and copyright information in PMC

References

    1. Ochini T, Nagata M, Nakajima K, et al. Transplantation. 1987 (in press) - PubMed
    1. Todo S, Makowka L, Starzl TE. Surg Res Comm. 1987 (in press) - PMC - PubMed
    1. Ochiai T, Nakajima K, Nagata M, et al. Transplant Proc. 1987;19:1284. - PubMed
    1. Lee P, Murase N, Todo S, et al. Surg Res Comm. 1987 (in press) - PMC - PubMed
    1. Murase N, Lee P, Lei H, et al. Transplant Proc. (this issue)

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