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. 1987 Oct;19(5 Suppl 6):89-92.

Toxicology of FK-506 in the Lewis rat

M A Nalesnik  1 , S Todo, N Murase, S Gryzan, P H Lee, L Makowka, T E Starzl
Affiliations

Toxicology of FK-506 in the Lewis rat

M A Nalesnik et al. Transplant Proc. 1987 Oct.
No abstract available

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Figures

Fig 1
Fig 1
Effect of FK on rat body weight. Group 1 (●); placebo; group 2 (○); 0.5 mg/kg/d; group 3 (■); 1.0 mg/kg/d; group 4 (□); 2.0 mg/kg/d; group 5 (▲); 4.0 mg/kg/d. Weights are represented as means. Number of animals per group: days 0, 3, 7, n = 25; days 10, 13, n = 20; days 17, 20, n = 15; days 24, 27, n = 10; days 31, 34, n = 5.
Fig 2
Fig 2
Effect of FK on thymus weight at day 34. Each bar represents the mean and SE of five animals per group killed on the last day of the experiment (day 34). Groups are as in Fig 1.
Fig 3
Fig 3
Thymus from FK-treated animal on day 7 shows a reduction of the medullary regions. This loss was progressive over time (H&E; original magnification ×32).
Fig 4
Fig 4
Pancreas from FK-treated animal showing small focus of necrotic acinar cells (H&E; original magnification ×325).
Fig 5
Fig 5
Lung from FK-treated rat showing perivascular eosinophilic infiltration. No direct vessel damage can be appreciated in this section. (H&E: original mangification ×325).
Fig 6
Fig 6
Effect of FK on blood glucose levels. Means and SE of blood glucose values were measured on days 7 and 34. Groups are as in Fig 1. Number of animals per group: day 7, 5; day 34, 5. □, Group 1; ●, group 3; ■, group 4; ○, group 5.
See this image and copyright information in PMC

References

    1. Ochiai T, Nakajima K, Nagata M, et al. Transplant Proc. 1987;19:1284. - PubMed
    1. Lee P, Murase N, Todo S, et al. Surg Res Comm (in press) - PMC - PubMed
    1. Todo S, Demetris A, Ueda Y, et al. Transplant Proc. this issue.
    1. Beschorner WE, Namnoum JD, Hess A, et al. Am J Pathol. 1987;126:487. - PMC - PubMed
    1. Hahn JH, Laube F, Lucke S, et al. Transplantation. 1986;41:44. - PubMed

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