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Comment
. 2014 Jan 22;18(1):404.
doi: 10.1186/cc13704.

Detrimental role of humoral signalling in cardio-renal cross-talk

Vincenzo Cantaluppi, Sergio Dellepiane, Alessandro D Quercia, Silvia Ferrario
Comment

Detrimental role of humoral signalling in cardio-renal cross-talk

Vincenzo Cantaluppi et al. Crit Care. .

Abstract

In critically ill patients, any acute organ injury is associated with a sudden change of circulating factors that may play a role in distant organ dysfunction through a complex cross-talk. In this issue, Virzì and colleagues discuss the relevance of humoral signalling between heart and kidney, focusing on type 1 and type 3 cardio-renal syndrome. We herein review the mechanisms of heart-kidney cross-talk, discussing the role of circulating detrimental mediators in the pathogenetic mechanisms of cardio-renal syndrome.

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References

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