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Review
. 2014 Mar;109(4):327-31.
doi: 10.1002/jso.23556. Epub 2014 Jan 22.

Intra-lesional interleukin-2 therapy for in transit melanoma

Claire F Temple-Oberle  1 , Brett A Byers, Valerie Hurdle, Allison Fyfe, J Gregory McKinnon
Affiliations
Review

Intra-lesional interleukin-2 therapy for in transit melanoma

Claire F Temple-Oberle et al. J Surg Oncol. 2014 Mar.

Abstract

Intra-lesional interleukin-2 (IL-2) is effective in treating in transit melanoma metastases. Results from multiple studies were examined to evaluate the efficacy of IL-2 for in transit disease. In the published literature, complete response ranged from 0% to 69% per patient, and 41% to 96% per lesion, with excellent tolerability. Combining the results of six studies show complete response in 50% of patients and 78% of lesions. Intra-lesional IL-2 should be considered early in the course of treatment for in transit disease, ahead of other, more toxic therapies.

Keywords: in-transit melanoma; interleukin-2; intra-lesional; melanoma.

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