Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013:2013:142358.
doi: 10.1155/2013/142358. Epub 2013 Dec 22.

Significant association between serum interleukin-6 and Helicobacter pylori antibody levels among H. pylori-positive Japanese adults

Hiroko Nakagawa  1 , Takashi Tamura  1 , Yoko Mitsuda  1 , Yasuyuki Goto  1 , Yoshikazu Kamiya  2 , Takaaki Kondo  3 , Kenji Wakai  1 , Nobuyuki Hamajima  4
Affiliations

Significant association between serum interleukin-6 and Helicobacter pylori antibody levels among H. pylori-positive Japanese adults

Hiroko Nakagawa et al. Mediators Inflamm. 2013.

Abstract

Background: Interleukin-6 (IL-6) is a multifunctional cytokine produced by many types of cells. Inflammation plays a key role in the pathogenesis of atherosclerosis that is an underlying cause of coronary heart disease (CHD). Since the 1990s, some studies have shown an association between H. pylori infection and CHD, which may be mediated by inflammation. Therefore, this study aimed to evaluate the association between serum anti-H. pylori IgG levels and serum IL-6 levels in H. pylori-infected adults.

Methods: We enrolled 158 subjects who visited a clinic located in an urban area to be tested for H. pylori infection, using the (13)C-urea breath test, and who were found to be infected and subsequently received eradication.

Results: The geometric mean serum IL-6 level was 1.78 pg/mL for men, 1.57 pg/mL for women, and 1.64 pg/mL overall. Logarithms of serum IL-6 levels were positively correlated with logarithms of serum H. pylori IgG levels (r = 0.24, P = 0.002). In multiple linear regression analysis adjusting for sex and age, the serum IL-6 level was still significantly associated with the IgG level in all subjects (β = 0.18, P = 0.012).

Conclusion: Higher H. pylori IgG levels were significantly associated with higher serum IL-6 levels among H. pylori-infected individuals.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Correlation between serum interleukin-6 and anti-H. pylori IgG titers among men (r = 0.27, P = 0.045, and n = 54).
Figure 2
Figure 2
Correlation between serum interleukin-6 and anti-H. pylori IgG titers among women (r = 0.23, P = 0.021, and n = 104).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Hirano T, Akira S, Taga T, Kishimoto T. Biological and clinical aspects of interleukin 6. Immunology Today. 1990;11(12):443–449. - PubMed
    1. Horii Y, Muraguchi A, Iwano M, et al. Involvement of IL-6 in mesangial proliferative glomerulonephritis. Journal of Immunology. 1989;143(12):3949–3955. - PubMed
    1. Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. The New England Journal of Medicine. 2005;352(16):1685–1695. - PubMed
    1. Mehta JL, Saldeen TGP, Rand K. Interactive role of infection, inflammation and traditional risk factors in atherosclerosis and coronary artery disease. Journal of the American College of Cardiology. 1998;31(6):1217–1225. - PubMed
    1. Ikonomidis I, Stamatelopoulos K, Lekakis J, Vamvakou GD, Kremastinos DT. Inflammatory and non-invasive vascular markers: the multimarker approach for risk stratification in coronary artery disease. Atherosclerosis. 2008;199(1):3–11. - PubMed

Publication types

LinkOut - more resources