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. 2013 Feb 27:7:37-42.
doi: 10.4137/CMRH.S10852.

Preimplantation genetic screening: a practical guide

Paul R Brezina  1 , Raymond W Ke  1 , William H Kutteh  1
Affiliations

Preimplantation genetic screening: a practical guide

Paul R Brezina et al. Clin Med Insights Reprod Health. .

Abstract

The past several decades have seen tremendous advances in the field of medical genetics. The application of genetic technologies to the field of reproductive medicine has ushered in a new era of medicine that is likely to greatly expand in the coming years. Concurrent with an in vitro fertilization (IVF) cycle, it is now possible to obtain a cellular biopsy from a developing embryo and genetically evaluate this sample with increasing sophistication and detail. Preimplantation genetic screening (PGS) is the practice of determining the presence of aneuploidy (either too many or too few chromosomes) in a developing embryo. However, how and in whom PGS should be offered is a topic of much debate.

Keywords: FISH; PGD; PGS; embryo; microarray; preimplantation genetic screening; recurrent pregnancy loss.

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Figures

Figure 1
Figure 1
Cleavage stage embryo. Notes: These photographs show an embryo at the cleavage stage. On the right is a photograph of a cleavage stage biopsy.
Figure 2
Figure 2
Blastocyst stage embryo. Notes: These photographs show an embryo at the Blastocyst stage. The leftmost photo shows the herniation of TE cells after the application of a laser to breach the zona pellucida. The next 2 photographs show the process of obtaining a sheet of trophectoderm (TE) cells that will be analyzed for PGS.
See this image and copyright information in PMC

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