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. 2013 Dec;45(4):303-12.
doi: 10.4143/crt.2013.45.4.303. Epub 2013 Dec 31.

Immunogenicity of influenza vaccine in colorectal cancer patients

Dong Ho Kim  1 , Yun Yong Lee  2 , Ui Sup Shin  3 , Sun Mi Moon  3
Affiliations

Immunogenicity of influenza vaccine in colorectal cancer patients

Dong Ho Kim et al. Cancer Res Treat. 2013 Dec.

Abstract

Purpose: Although influenza is regarded as a major cause of morbidity and mortality in immunocompromised patients, vaccine coverage remains poor. We evaluated the immunogenicity of influenza vaccines in colorectal cancer patients.

Materials and methods: In this study, 40 colorectal cancer patients who received an influenza vaccine at the Korea Cancer Center Hospital during the 2009-2010 and 2010-2011 influenza seasons were analyzed. The blood samples were collected at prevaccination and 30 days post vaccination, and antibody titers were measured using the hemagglutination-inhibition tests.

Results: In the 2009-2011 season, the seroprotection rate for H1N1 (94.7%) was significantly higher than that for H3N2 (42.1%) and B (47.3%). The seroconversion rate was 52.6%, 26.3%, and 36.8% for H1N1, H3N2, and B, respectively. Fold increase of geometric mean titer (MFI) was 3.86, 1.49, and 3.33 for H1N1, H3N2, and B, respectively. In the 2010-2011 season, the seroprotection rate for H1N1 (57.1%) was significantly higher than that for H3N2 (52.4%) and B (38.1%). The seroconversion rate was 52.4%, 47.6% and 33.3% for H1N1, H3N2, and B, respectively. MFI was 12.29, 3.62 and 4.27 for H1N1, H3N2, and B, respectively.

Conclusion: Our study cohort showed an acceptable immune response to an influenza vaccine without significant adverse effects, supporting the recommendation for annual influenza vaccination in colorectal cancer patients.

Keywords: Colorectal neoplasms; Hemagglutination inhibition tests; Human influenza; Influenza vaccines.

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Conflict of interest statement

Conflict of interest relevant to this article was not reported.

Figures

Fig. 1
Fig. 1
Linear regression analysis between age of subjects and their hemagglutination inhibition (HI) titer.
Fig. 2
Fig. 2
Linear regression analysis between total chemotherapy duration and their hemagglutination inhibition (HI) titer.
See this image and copyright information in PMC

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