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Review
. 2014 Jan 10:4:175.
doi: 10.3389/fphar.2013.00175.

Population-based colorectal cancer screening: comparison of two fecal occult blood test

Miren B Zubero  1 , Eunate Arana-Arri  2 , José I Pijoan  3 , Isabel Portillo  4 , Isabel Idigoras  4 , Antonio López-Urrutia  5 , Ana Samper  6 , Begoña Uranga  7 , Carmen Rodríguez  8 , Luis Bujanda  9
Affiliations
Review

Population-based colorectal cancer screening: comparison of two fecal occult blood test

Miren B Zubero et al. Front Pharmacol. .

Abstract

Background: The aim of screening for colorectal cancer is to improve prognosis by the detection of cancer at its early stages. In order to inform the decision on the specific test to be used in the population-based program in the Basque Autonomous Region (Spain), we compared two immunochemical fecal occult blood quantitative tests (I-FOBT).

Methods: Residents of selected study areas, aged 50-69 years, were invited to participate in the screening. Two tests based on latex agglutination (OC-Sensor and FOB Gold) were randomly assigned to different study areas. A colonoscopy was offered to patients with a positive test result. The cut-off point used to classify a result as positive, according to manufacturer's recommendations, was 100 ng/ml for both tests.

Results: The invited population included 37,999 individuals. Participation rates were 61.8% (n = 11,162) for OC-Sensor and 59.1% (n = 11,786) for FOB Gold (p = 0.008). Positive rate for OC-Sensor was 6.6% (n = 737) and 8.5% (n = 1,002) for FOB Gold (p < 0.0001). Error rates were higher for FOB gold (2.3%) than for OC-Sensor (0.2%; p < 0.0001). Predictive positive value (PPV) for total malignant and premalignant lesions was 62.4% for OC-Sensor and 58.9% for FOB Gold (p = 0.137), respectively.

Conclusion: OC-Sensor test appears to be superior for I-FOBT-based colorectal cancer screening, given its acceptance, ease of use, associated small number of errors and its screening accuracy. FOB Gold on the other hand, has higher rate of positive values, with more colonoscopies performed, it shows higher detection incidence rates, but involves more false positives.

Keywords: colorectal cancer; health impact assessment; health outcomes research; immunochemical fecal occult blood test; population screening.

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References

    1. Allison J. E., Sakoda L. C., Levin T. R., Tucker J. P., Tekawa I. S., Cuff T., et al. (2007). Screening for colorectal neoplasms with new fecal occult blood tests: update on performance characteristics. J. Natl. Cancer Inst. 99 1462–147010.1093/jnci/djm150 - DOI - PubMed
    1. Australian Institute of Health and Welfare. (2012). National Bowel Cancer Screening Program Monitoring Report: Phase 2, July 2008–June 2011. Cancer Series NO. 65. Cat. No. CAN 61. Canberra: AIHW. Available at: http://www.aihw.gov.au/WorkArea/DownloadAsset.aspx?id=10737421401 (accessed on September 5, 2013)
    1. Barros A. J. D., Hirakata V. N. (2003). Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. BMC Med. Res. Methodol. 3:2110.1186/1471-2288-3-21 - DOI - PMC - PubMed
    1. Bartus T. (2005). Estimation of marginal effects using margeff. Stata J. 3 309–329
    1. Castells A., Mar-Castillejo M., Mascort J. J., Amador F. J., Giraldez M. D., Andreu M., et al. (2009). Guïa de Práctica Clïnica. Prevención del Cáncer Colorrectal. Update 2009. Gastroenterol. Hepatol. 32 717–758 - PubMed

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