Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013:2013:696423.
doi: 10.1155/2013/696423. Epub 2013 Dec 25.

(18)F-FLT PET/CT in Patients with Gastric Carcinoma

Bogdan Małkowski  1 , Tomasz Staniuk  2 , Ewa Srutek  3 , Tomasz Gorycki  4 , Wojciech Zegarski  2 , Michał Studniarek  4
Affiliations

(18)F-FLT PET/CT in Patients with Gastric Carcinoma

Bogdan Małkowski et al. Gastroenterol Res Pract. 2013.

Abstract

The aim of the study was to evaluate the usefulness of 18F-FLT PET/CT in the detection and differentiation of gastric cancers (GC). 104 consecutive patients (57 cases of adenocarcinoma tubulare (G2 and G3), 17 cases of mucinous adenocarcinoma, 6 cases of undifferentiated carcinoma, 14 cases of adenocarcinoma partim mucocellulare, and 10 cases of end stage gastric cancer) with newly diagnosed advanced gastric cancer were examined with FLT PET/CT. For quantitative and comparative analyses, the maximal standardized uptake value (SUVmax) was calculated for both the tumors and noninvaded gastric wall. Results. There were found, in the group of adenocarcinoma tubulare, SUVmax 1.5-23.1 (7.46 ± 4.57), in mucinous adenocarcinoma, SUVmax 2.3-10.3 (5.5 ± 2.4), in undifferentiated carcinoma, SUVmax 3.1-13.6 (7.28 ± 3.25), in adenocarcinoma partim mucocellulare, SUVmax 2-25.3 (7.7 ± 6.99), and, in normal gastric wall, SUVmax 1.01-2.55 (1.84 ± 0.35). For the level of 2.6 cut-off value between the normal wall and neoplasm FLT uptake from ROC analysis, all but five gastric cancers showed higher accumulation of FLT than noninfiltrated mucosa. Conclusion. Gastric cancer presents higher accumulation of 18F-FLT than normal, distended gastric mucosa. Significantly higher accumulation was shown in cancers better differentiated and with higher cellular density.

PubMed Disclaimer

Figures

Figure 1
Figure 1
(a) 18FLT-PET in patient with undifferentiated adenocarcinoma. SUVmax⁡ in normal gastric wall was 1.8. (b) 18FLT-PET in patient with undifferentiated adenocarcinoma. SUVmax⁡ = 8.9.
Figure 2
Figure 2
18FLT-PET in patient with mucinous adenocarcinoma. SUVmax⁡ = 5.9.
Figure 3
Figure 3
18FLT-PET in patient with adenocarcinoma tubulare G2 (G3). SUVmax⁡ = 7.32.
See this image and copyright information in PMC

References

    1. Wojciechowska U, Didkowska J, Zatoński W. Cancer in Poland in 2010. Warsaw, Poland: Centrum Onkologii; 2012.
    1. Mochiki E, Kuwano H, Katoh H, Asao T, Oriuchi N, Endo K. Evaluation of 18F-2-deoxy-2-fluoro-D-glucose positron emission tomography for gastric cancer. World Journal of Surgery. 2004;28(3):247–253. - PubMed
    1. Stahl A, Ott K, Weber WA, et al. FDG PET imaging of locally advanced gastric carcinomas: correlation with endoscopic and histopathological findings. European Journal of Nuclear Medicine and Molecular Imaging. 2003;30(2):288–295. - PubMed
    1. Shields AF, Grierson JR, Dohmen BM, et al. Imaging proliferation in vivo with [F-18]FLT and positron emission tomography. Nature Medicine. 1998;4(11):1334–1336. - PubMed
    1. Staniuk T, Zegarski W, Malkowski B, Jankowski M, Klag M, Pietrzak T. Evaluation of 18F-FLT PET/CT usefulness in diagnosis and qualification for surgical treatment of gastric cancer. Współczesna Onkologia. 2013;(2):165–170. - PMC - PubMed

LinkOut - more resources