Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Oct;5(4):22-33.

The role of integrins in the development and homeostasis of the epidermis and skin appendages

A L Rippa  1 , E A Vorotelyak  2 , A V Vasiliev  1 , V V Terskikh  1
Affiliations

The role of integrins in the development and homeostasis of the epidermis and skin appendages

A L Rippa et al. Acta Naturae. 2013 Oct.

Abstract

Integrins play a critical role in the regulation of adhesion, migration, proliferation, and differentiation of cells. Because of the variety of the functions they play in the cell, they are necessary for the formation and maintenance of tissue structure integrity. The trove of data accumulated by researchers suggests that integrins participate in the morphogenesis of the epidermis and its appendages. The development of mice with tissue-specific integrin genes knockout and determination of the genetic basis for a number of skin diseases in humans showed the significance of integrins in the biology, physiology, and morphogenesis of the epidermis and hair follicles. This review discusses the data on the role of different classes of integrin receptors in the biology of epidermal cells, as well as the development of the epidermis and hair follicles.

Keywords: basement membrane; differentiation; hair follicle; integrins; keratinocytes; migration; morphogenesis; proliferation; stem cells.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Schematic representation of the heterodimeric integrin receptors family [1, 2]
Fig. 2
Fig. 2
The principle of action of extracellular signals on intracellular environment processes through integrin receptors
Fig. 3
Fig. 3
Integrin receptors in cell-matrix interactions
Fig. 4
Fig. 4
The structure of the hair follicle [36]
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Hynes R.O.. Cell. 2002;110(6):673–687. - PubMed
    1. Barczyk M., Carracedo S., Gullberg D.. Cell Tissue Res. 2010;339(1):269–280. - PMC - PubMed
    1. Bouvard B., Brakebusch C., Gustafsson E., Aszódi A., Bengtsson T., Berna A., Fässler R.. Circ. Res. 2001;89(3):211–223. - PubMed
    1. Bokel C., Brown N.H.. Dev. Cell. 2002;3(3):311–321. - PubMed
    1. Stenn K.S., Paus R.. Physiol. Rev. 2001;81(1):449–494. - PubMed

LinkOut - more resources