Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013:2013:580968.
doi: 10.1155/2013/580968. Epub 2013 Dec 22.

Type I Interferon at the Interface of Antiviral Immunity and Immune Regulation: The Curious Case of HIV-1

Adriano Boasso  1
Affiliations
Review

Type I Interferon at the Interface of Antiviral Immunity and Immune Regulation: The Curious Case of HIV-1

Adriano Boasso. Scientifica (Cairo). 2013.

Abstract

Type I interferon (IFN-I) play a critical role in the innate immune response against viral infections. They actively participate in antiviral immunity by inducing molecular mechanisms of viral restriction and by limiting the spread of the infection, but they also orchestrate the initial phases of the adaptive immune response and influence the quality of T cell immunity. During infection with the human immunodeficiency virus type 1 (HIV-1), the production of and response to IFN-I may be severely altered by the lymphotropic nature of the virus. In this review I consider the different aspects of virus sensing, IFN-I production, signalling, and effects on target cells, with a particular focus on the alterations observed following HIV-1 infection.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Bekisz J, Schmeisser H, Hernandez J, Goldman ND, Zoon KC. Human interferons alpha, beta and omega. Growth Factors. 2004;22(4):243–251. - PubMed
    1. Neil SJ. The antiviral activities of tetherin. Current Topics in Microbiology and Immunology. 2013;371:67–104. - PubMed
    1. Samuel CE. Antiviral actions of interferons. Clinical Microbiology Reviews. 2001;14(4):778–809. - PMC - PubMed
    1. Scagnolari C, Antonelli G. Antiviral activity of the interferon alpha family: biological and pharmacological aspects of the treatment of chronic hepatitis c. Expert Opinion on Biological Therapy. 2013;13:693–711. - PubMed
    1. Kalinke U, Prinz M. Endogenous, or therapeutically induced, type I interferon responses differentially modulate Th1/Th17-mediated autoimmunity in the CNS. Immunology and Cell Biology. 2012;90:505–509. - PMC - PubMed