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. 2013 Jul;2(3):137-9.
doi: 10.4103/2278-330X.114119.

The role of surgery in locally advanced carcinoma of cervix after sub-optimal chemoradiation: Indian scenario

Rajshekar S Kundargi  1 , B Guruprasad  2 , Nikesh Hanumantappa  3 , Praveen Shankar Rathod  1 , Uma K Devi  1 , U D Bafna  1
Affiliations

The role of surgery in locally advanced carcinoma of cervix after sub-optimal chemoradiation: Indian scenario

Rajshekar S Kundargi et al. South Asian J Cancer. 2013 Jul.

Abstract

Background: Standard treatment of advanced cervical cancer is concurrent chemoradiation. Radical radiotherapy for carcinoma cervix includes pelvic external beam radiotherapy (EBRT) with the concomitant platinum based chemotherapy followed by intracavitary brachytherapy (ICBT) to boost central disease. Management of patients who are suboptimally treated, especially, after unsuccessful ICBT insertion is not well-defined. This study explores the role of hysterectomy in these patients.

Materials and methods: From January 2006 to December 2011, 38 patients with locally advanced cervical cancer, in whom ICBT insertion was unsuccessful, were analyzed retrospectively. Operable patients with no parametrial involvement underwent hysterectomy and outcomes (recurrence free and overall survival) were noted.

Results: The major complications in post operative period were wound infection, paralytic ileus and bladder atony all of which were conservatively managed with no mortality. At median follow-up of 36 months (range 12-60 months) there was no recurrence in patients with stage 1B2 and stage IIA, 25 out of 38 (65.8%) were event free and the overall survival was 71%.

Conclusion: Many patients in Indian scenario receive suboptimal therapy in locally advanced cervical cancer. EBRT with chemotherapy followed by type 1 extra-fascial hysterectomy can be a good alternative for these patients.

Keywords: Carcinoma cervix; hysterectomy; unsuccessful intracavitary brachytherapy.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Post-external beam radiotherapy with a small cervical residual disease, in a patient who defaulted intracavitary brachytherapy
Figure 2
Figure 2
Overall survival
See this image and copyright information in PMC

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References

    1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90. - PubMed
    1. Green JA, Kirwan JM, Tierney JF, Symonds P, Fresco L, Collingwood M, et al. Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: A systematic review and meta-analysis. Lancet. 2001;358:781–6. - PubMed
    1. Coia L, Won M, Lanciano R, Marcial VA, Martz K, Hanks G. The Patterns of Care Outcome Study for cancer of the uterine cervix. Results of the Second National Practice Survey. Cancer. 1990;66:2451–6. - PubMed
    1. Logsdon MD, Eifel PJ. Figo IIIB squamous cell carcinoma of the cervix: An analysis of prognostic factors emphasizing the balance between external beam and intracavitary radiation therapy. Int J Radiat Oncol Biol Phys. 1999;43:763–75. - PubMed
    1. Walji N, Chue AL, Yap C, Rogers LJ, El-Modir A, Chan KK, et al. Is there a role for adjuvant hysterectomy after suboptimal concurrent chemoradiation in cervical carcinoma? Clin Oncol (R Coll Radiol) 2010;22:140–6. - PubMed