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. 2014;16(3):290-5.
doi: 10.1080/10286020.2013.878332.

Microbial transformation of resibufogenin by Curvularia lunata AS 3.4381

Xiu-Lan Xin  1 , Jiang-Hao Sun, Xiao-Bo Wang, Rong-Gang Xi, Gang Wang, Rong Lan, Dong-Hai Su, Hua Li, Xiao-Kui Huo, Chao Wang
Affiliations

Microbial transformation of resibufogenin by Curvularia lunata AS 3.4381

Xiu-Lan Xin et al. J Asian Nat Prod Res. 2014.

Abstract

In this paper, the microbial transformation of resibufogenin by Curvularia lunata AS 3.4381 was investigated, and four transformed products were isolated and characterized as 3-epi-resibufogenin (2), 12α-hydroxy-3-epi-resibufogenin (3), 12-oxo-16β-hydroxy-3-epi-resibufogenin (4), and 12β,15-epoxy-3-epi-bufalin-14,15-ene (5). Among them, 4 and 5 are new compounds, and isomerization, hydroxylation, and oxidation reactions in microbial transformation process were observed. Additionally, the cytotoxicities of transformed products (2-5) were also investigated.

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