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Randomized Controlled Trial
. 2014 Mar;103(3):e18-23.
doi: 10.1016/j.diabres.2013.12.044. Epub 2014 Jan 6.

Vitamin-D supplementation in prediabetes reduced progression to type 2 diabetes and was associated with decreased insulin resistance and systemic inflammation: an open label randomized prospective study from Eastern India

Deep Dutta  1 , Samim Ali Mondal  2 , Subhadip Choudhuri  3 , Indira Maisnam  4 , Abu Hena Hasanoor Reza  5 , Basudeb Bhattacharya  6 , Subhankar Chowdhury  7 , Satinath Mukhopadhyay  8
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Randomized Controlled Trial

Vitamin-D supplementation in prediabetes reduced progression to type 2 diabetes and was associated with decreased insulin resistance and systemic inflammation: an open label randomized prospective study from Eastern India

Deep Dutta et al. Diabetes Res Clin Pract. 2014 Mar.

Abstract

Vitamin-D supplementation in vitamin-D insufficient/deficient prediabetes individuals is associated with significantly lower progression to diabetes (6/55 vs. 13/49; p=0.04) and higher reversal to normoglycemia (23/55 vs. 10/49; p=0.02), associated with decreased insulin resistance and systemic inflammation (TNFα and IL6). Baseline vitamin-D and 2h blood glucose independently predicted progression to diabetes.

Keywords: Diabetes; Insulin resistance; Prediabetes; Systemic inflammation; Vitamin-D.

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